I've seen others complaining about this, but I really can't find any problem with it.
Works out of the box no need to run any software, just plug in, let it get an IP address and start using it.
If you want to do more detailed configuration browse to its IP address and login with the easily guessable username and password (I'd suggest you change them). The UI is perfectly OK and usable for anyone with a modicum of knowledge of these things.
Works with XP, Vista, Mac OSX and Ubuntu Linux with no problems. Can't speak for any other platform, but if it works with Mac OSX and Ubuntu it should work with anything that supports Samba. I didn't try AppleTalk as there seemed no point.
As for the noise people have complained of, mine is barely audible. If you put it on a desk or other hard surface you may need to put something soft under it to stop some vibration hum, but then it does have a lump of metal spinning at 7200 RPM inside it, so it will vibrate a little, as would any other device.
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Overall

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Ease of use
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Value for money
